Flight telerobotic servicer control from the Orbiter

The research and work conducted on the development of a testbed for a display and control panel for the Flight Telerobotic Servicer (FTS) are presented. Research was conducted on both software and hardware needed to control the FTS. A breadboard was constructed and placed into a mockup of the aft station of the Orbiter spacecraft. This breadboard concept was then evaluated using a computer graphics representation of the Tinman FTS. Extensive research was conducted on the software requirements and implementation. The hardware selected for the breadboard was 'flight like' and in some cases fit and function evaluated. The breadboard team studied some of the concepts without pursuing in depth their impact on the Orbiter or other missions. Assumptions are made concerning payload integration

The HF Radar National Server and Architecture Project

This project attempts to advance the utilization of existing HF Radar resources through the addition of a robust data management and communications architecture and the single-point delivery of data on a national basis. This is intended also to provide a demonstration of the capability of HF Radar technology to address the need for surface current information. As the project\u27s quality control initiatives are implemented, it is expected that HF Radar product development will occur that will further demonstrate and increase capability. The groundwork will thus be laid for a national decision on the implementation of a robust, operational HF Radar system as a major component of the IOOS

Immunodynamics: a cancer immunotherapy trials network review of immune monitoring in immuno-oncology clinical trials

International audienceThe efficacy of PD-1/PD-L1 targeted therapies in addition to anti-CTLA-4 solidifies immunotherapy as a modality to add to the anticancer arsenal. Despite raising the bar of clinical efficacy, immunologically targeted agents raise new challenges to conventional drug development paradigms by highlighting the limited relevance of assessing standard pharmacokinetics (PK) and pharmacodynamics (PD). Specifically, systemic and intratumoral immune effects have not consistently correlated with standard relationships between systemic dose, toxicity, and efficacy for cytotoxic therapies. Hence, PK and PD paradigms remain inadequate to guide the selection of doses and schedules, both starting and recommended Phase 2 for immunotherapies. The promise of harnessing the immune response against cancer must also be considered in light of unique and potentially serious toxicities. Refining immune endpoints to better inform clinical trial design represents a high priority challenge. The Cancer Immunotherapy Trials Network investigators review the immunodynamic effects of specific classes of immunotherapeutic agents to focus immune assessment modalities and sites, both systemic and importantly intratumoral, which are critical to the success of the rapidly growing field of immuno-oncology

Immunodynamics: a cancer immunotherapy trials network review of immune monitoring in immuno-oncology clinical trials.

The efficacy of PD-1/PD-L1 targeted therapies in addition to anti-CTLA-4 solidifies immunotherapy as a modality to add to the anticancer arsenal. Despite raising the bar of clinical efficacy, immunologically targeted agents raise new challenges to conventional drug development paradigms by highlighting the limited relevance of assessing standard pharmacokinetics (PK) and pharmacodynamics (PD). Specifically, systemic and intratumoral immune effects have not consistently correlated with standard relationships between systemic dose, toxicity, and efficacy for cytotoxic therapies. Hence, PK and PD paradigms remain inadequate to guide the selection of doses and schedules, both starting and recommended Phase 2 for immunotherapies. The promise of harnessing the immune response against cancer must also be considered in light of unique and potentially serious toxicities. Refining immune endpoints to better inform clinical trial design represents a high priority challenge. The Cancer Immunotherapy Trials Network investigators review the immunodynamic effects of specific classes of immunotherapeutic agents to focus immune assessment modalities and sites, both systemic and importantly intratumoral, which are critical to the success of the rapidly growing field of immuno-oncology

The Domestication of Annatto (Bixa orellana) from Bixa urucurana in Amazonia

Annatto (Bixa orellana) is an important colorant domesticated in theNeotropics, although it is not clear where or from which wild populations. We reviewed the available biological, archaeological, and ethnographic information about annatto, and integrated this with our recent ethnobotanical observations of cultivated and non-cultivated populations in order to evaluate the hypothesis thatwhat is classified as Bixa urucurana is the wild ancestor of cultivated annatto, Bixa orellana. Most B. urucurana populations we found in Amazonia occurred in open forests or anthropogenic landscapes, although never cultivated, and always associated with riparian environments. While cultivated annatto always produces abundant pigment, B. urucurana populations that we observed contained variable amounts of pigment, fromvery little to nearly the amount of cultivated annatto, suggesting gene flow fromcultivated to non-cultivated. Bixa urucurana has indehiscent fruits, which indicate changes in dehiscence during annatto domestication, a notable feature rarely found in other tree species. Local residents identified the non-cultivated populations aswild annatto (urucum bravo), and they emphasized their smaller fruits with less pigment, their spontaneous regeneration, their non-use, and that they hybridize with cultivated annatto. Ethnography identified the symbolic importance of annatto, but an explicit mention of origin only comes from southern Amazonia. Although the oldest annatto archaeological record came from the Caribbean, domestication occurred in northern South America, since B. urucurana does not occur in the Caribbean. Traditional ecological knowledge and morphology identified the close relationship between B. urucurana (never cultivated) and B. orellana (always cultivated). Evidence reported here strongly supports Kuntze's (1925) suggestion that Bixa urucurana Willd. is a variety of B. orellana L., thus identifying the wild ancestor of cultivated annatto. © 2015, by The New York Botanical Garden Press, Bronx, NY 10458-5126 U.S.A

Understanding Genetic Diversity and Population Structure of a <i>Poa pratensis</i> Worldwide Collection through Morphological, Nuclear and Chloroplast Diversity Analysis

<div><p><i>Poa pratensis</i> L. is a forage and turf grass species well adapted to a wide range of mesic to moist habitats. Due to its genome complexity little is known regarding evolution, genome composition and intraspecific phylogenetic relationships of this species. In the present study we investigated the morphological and genetic diversity of 33 <i>P</i>. <i>pratensis</i> accessions from 23 different countries using both nuclear and chloroplast molecular markers as well as flow cytometry of somatic tissues. This with the aim of shedding light on the genetic diversity and phylogenetic relationships of the collection that includes both cultivated and wild materials. Morphological characterization showed that the most relevant traits able to distinguish cultivated from wild forms were spring growth habit and leaf colour. The genome size analysis revealed high variability both within and between accessions in both wild and cultivated materials. The sequence analysis of the <i>trn</i>L-F chloroplast region revealed a low polymorphism level that could be the result of the complex mode of reproduction of this species. In addition, a strong reduction of chloroplast SSR variability was detected in cultivated materials, where only two alleles were conserved out of the four present in wild accessions. Contrarily, at nuclear level, high variability exist in the collection where the analysis of 11 SSR loci allowed the detection of a total of 91 different alleles. A Bayesian analysis performed on nuclear SSR data revealed that studied materials belong to two main clusters. While wild materials are equally represented in both clusters, the domesticated forms are mostly belonging to cluster P2 which is characterized by lower genetic diversity compared to the cluster P1. In the Neighbour Joining tree no clear distinction was found between accessions with the exception of those from China and Mongolia that were clearly separated from all the others.</p></div